Lupus erythematosus profundus LEP is a clinical subtype of cutaneous lupus erythematosus that has a chronic and recurrent clinical course. Systemic corticosteroids, which are often administered in cases of LEP complicated with systemic lupus erythematosus, are generally effective but cause side effects. Thus, other therapeutic options are needed. Related to lupus profundus: panniculitis, lupus tumidus lu·pus er·y·the·ma·to·sus pro·fun·dus a subcutaneous panniculitis with marked lymphocyte infiltration of fat lobules giving rise to deep-seated, firm, rubbery nodules that sometimes become ulcerated, usually of the face; may occur in systemic and localized lupus erythematosus. Some patients present with localized depressions without erythema, clinically resembling lipoatrophy. The term lupus profundus has been used both for lupus panniculitis and also for discoid lupus erythematosus lesions that involve the dermis and extend deeply into the subcutis. Over time, lesions that begin as pure panniculitis can develop. Wätzig V et al. 1989 Lupus panniculitis Lupus erythematodes profundus. Akt Dermatol 15: 109-111 Akt Dermatol 15: 109-111 Wimmershoff MB et al. 2003 Discoid lupus erythematosus and lupus profundus in childhood: a report of two cases.
Conversely, between ten and 50 percent of patients with lupus panniculitis will have or eventually develop systemic lupus erythematosus. Most patients are adults between 20 and 60 years old, with a female to male ratio of approximately two to one. Lupus panniculitis is a chronic condition that often involves persistent lesions that subsequently heal with disfigurement. Lupus erythematodes profundus LEP Der Lupus erythematodes profundus lat. profundus = tiefliegend LEP, auch Lupus-Pannikulitis genannt, ist eine seltene Form des kutanen Lupus erythematodes CLE mit derben Knoten im subkutanen Fettgewebe von Gesicht, Schultern, Gesäß und Extremitäten. Die darüberliegende Haut kann normal aussehen. Lupus erythematosus is an uncommon group of skin conditions which typically affect women ages 20 to 50. LE may take various forms. LE may take various forms. Discoid lupus erythematosus is the most common form of LE, and consists of the formation of scaly patches of skin which are red in color, typically on the nose, ears, and/or cheeks. Abstract:Lupus erythematosus panniculitis, also known as lupus profundus, is a variant in the clinicopathological spectrum of lupus erythematosus LE affecting about 2%–3% of LE patients. A linear configuration of LE panniculitis has been reported. ii. Lupus Erythematosus Profundus. LE profundus LEP, or panniculitis, features painful firm subcutaneous nodules with occasionally overlying DLE occurring in areas of increased fat deposition, such as the upper arms and legs, face, and breasts.
Lupus erythematosus profundus in a patient with dermatomyositis. T. Miura. Department of Dermatology, Fukushima Medical University, Fukushima, Japan. Search for more papers by this author. T. Mori. Department of Dermatology, Fukushima Medical University, Fukushima, Japan. Search for more papers by this author. T. Ito. Department of Dermatology, Fukushima Medical University, Fukushima,. 田中光彦, 高井修平, 小林茂人 他: Lupus erythematosus profundusの1症例, 日本臨床免疫学会会誌, 16: 397-402, 1993 6. 稲垣安紀 他: Lupus erythematosus profundus, 臨皮, 39: 549-554, 1985 7. 小川喜美子, 飯島正文, 紫芝敬子 他: Lupus Erythematosus Profundus, 臨皮, 32: 17-27, 1978. Lupus erythematosus LE panniculitis profundus is an unusual clinical variant of lupus erythematosus in which the cutaneous inflammatory reaction occurs primarily in the deeper corium.
Lupus Erythematosus Profundus - Panniculite lupique - Synonyme: Lupus érythémateux profond - panniculite lupique - Forme de lupus érythémateux caractérisée par des nodules dermiques profonds ou sous-cutanés que l'on retrouve sur la tête, le visage ou la partie supérieure des bras. Lupus erythematosus hypertrophicus et profundus is notoriously recalcitrant to treatment, even more so than lupus erythematosus of the lower lids. Yet, in my experience persistent treatment eventually brings about satisfactory results, particularly if the doses of either gold •or bismuth are kept as high as possible with safety. In other words. Lupus erythematosus panniculitis LEP, an uncommon variant in the clinicopathological spectrum of lupus erythematosus LE, is rare. There are only a few reported series of patients with this condition; none in individuals of North African ancestry. Kaposi Kohn first described the histologic features of subcutaneous nodules in lupus erythematosus in 1883, although he did not use the term “profundus” in his description.1 He described the histopathology of these subcutaneous nodules as an inflammatory reaction in the superficial dermis, as well as the deeper dermis and subcutaneous fat. lupus lo͞o`pəs, noninfectious chronic disease in which antibodies in an individual's immune system attack the body's own substances. In lupus, known medically as lupus erythematosus, antibodies are produced against the individual's own cells, causing tissue inflammation and cell damage.
W. K. Jacyk MD and; K. N. Bhana MD; Article first published online: 30 MAY 2006. DOI: 10.1111/j.1365-4632.2006.02770.x. Sir, In 1883, Kaposi, first, described the association of subcutaneous nodules with lupus erythematosus. This finding has subsequently being recognized as LE profundus, more accurately, LE.
A case of lupus erythematosus profundus, with associated mastitis, but without any lesions of discoid lupus erythematosus or systemic lupus erythematosus is being reported. Conversely, between 10%-15% of patients with lupus profundus will have or eventually develop systemic disease [2,3]. Lupus profundus was seen in 6/228 2.6% and 4/86 4.6% in two series of discoid lupus DLE patients. Despite all the above lupus profundus is not considered as a criterion for the classification of SLE.
Lupus erythematosus LE comprises an uncommon group of connective tissue disorders. The main types of lupus are discoid lupus erythematosus DLE, subacute cutaneous lupus erythematosus SCLE and systemic lupus erythematosus. The aim of this chapter, which is set out as below, is to highlight the key features of these conditions. Lupus erythematosus profundus or panniculitis LEP is an unusual but distinct clinical variety of lupus erythematosus. The inflammatory reaction in LEP takes place primarily in the deep corium and the subcutaneous tissues leading to deep indurated nodules or sharply defined plaques.
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